小诺霉素为一最新的氨基糖甙类抗生素由于其肾毒性和耳毒性低的优点,临床应用日趋广泛,特别是静脉给药,但目前尚未见到有关与输液配伍的研究报道,本文采用荧光分光光度法测定小诺霉素与十种常用输液配伍后的含量变化,并测定配伍后不同时间的pH和外观观察,为临床合理用药提供依据。 Because of its advantages of low nephrotoxicity and ototoxicity, microtomycin is a new aminoglycoside antibiotic and its clinical application is more and more widespread, especially intravenous administration. However, there is no report about the compatibility with infusion solution. In this paper, Fluorescence spectrophotometry was used to determine the change of content between the microtomyelin and the ten common infusions. The pH and appearance of the microtomycin at different time after the compatibility were determined, which provided the basis for clinical rational drug use.