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以萜品油烯(terpinolene)与2,4-二氧代戊酸甲酯的de Mayo反应得到的加成产物为起始原料,经反-aldol重排,再环合成具有螺[5.5]十一烷结构的基本碳架,通过官能团的化学修饰,完成了(±)-α-花柏烯和(±)-β-花柏烯的全合成.
Starting from the addition product of de Mayo reaction of terpinolene and methyl 2,4-dioxopentanoate, the product was re-cycled via trans-aldol, The basic carbon skeleton of mono-alkane structure, the chemical modification of the functional groups completes the total synthesis of (±) -α-secundin and (±) -β-secunene.