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Key factsrnDefinition of retinoblastoma (RB):Malignant primary neoplasm of the retina. Classic imaging appearance:CT shows an intraocular enhancing retinal mass with calcification often with retinal detachment.rnMost common intraocular tumor of childhood.rnPresents with leukocoria.rnUnilateral much more than bilateral (autosomal dominant).rnRarely trilateral or tetralateral ( co-existing pineal and/or suprasellar primi-tive neuroectodermal tumor).