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对４８例子宫内膜增生，２４例子宫内膜癌进行了血甾体激素放免分析及组织雌、孕激素受体生化定量检测，对３８例子宫内膜增生及２２例子宫内膜癌进行了受体免疫组化定性检测，对６例子宫内膜增生及１２例子宫内膜癌进行了扫描电镜及透射电镜观察。结果表明，子宫内膜增生与内膜癌之间血甾体激素水平无明显差别。但绝经后的子宫内膜增生及内膜癌患者的雌激素水平高于正常绝经后的妇女；从子宫内膜增生，腺囊样增生，腺瘤样增生到内膜癌，其雌、孕激素受体含量逐渐降低；受体含量与临床分期、细胞分化程度、宫颈浸润、肌层浸润及复发情况相关。经对雌、孕激素受体的定性分析，子宫内膜增生阳性率近１００％，非典型增生及原位癌为８３．３３％，内膜癌为７５％及８１．２５％。电镜观察子宫内膜增生的雌激素依赖性结构明显增加，而内膜癌的雌激素依赖性结构减少，细胞器形态排列异常伴有核异型性及核小体，并出现假包涵体。
Forty-eight cases of endometrial hyperplasia and 24 cases of endometrial cancer were studied by radioimmunoassay of serum steroid hormones and biochemical quantification of estrogen receptor and progesterone receptor in 38 cases of endometrial hyperplasia and 22 cases of endometrial carcinoma Receptor immunohistochemical qualitative detection, 6 cases of endometrial hyperplasia and 12 cases of endometrial cancer were observed by scanning electron microscopy and transmission electron microscopy. The results show that there is no significant difference between endometrial hyperplasia and endometrial cancer serum steroid hormone levels. However, postmenopausal endometrial hyperplasia and endometrial cancer in patients with estrogen levels higher than normal postmenopausal women; from the endometrial hyperplasia, cystoid hyperplasia, adenoma-like hyperplasia to endometrial cancer, the estrogen and progesterone The content of receptor decreased with the clinical stage, cell differentiation, cervical infiltration, myometrial invasion and recurrence. The qualitative analysis of estrogen and progesterone receptors, the positive rate of endometrial hyperplasia nearly 100%, atypical hyperplasia and carcinoma in situ was 83.33%, endometrial cancer was 75% and 81.25%. Electron microscopy showed that endometrial hyperplasia estrogen-dependent structure increased significantly, while the endometrial cancer estrogen-dependent structure decreased, organelles with abnormal arrangement of nuclear atypia and nucleosomes, and fake inclusions.