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血脑屏障的破坏是脑外伤后重要的病理生理改变之一,直接影响脑外伤患者的病程与预后。目前,对脑外伤后血脑屏障破坏及通透性改变的检测越来越受到关注。文章就脑外伤后血脑屏障的破坏及其检测的重要性、血脑屏障破坏的检测方法做概述,并重点就动态对比增强MRI(DCE-MRI)对脑外伤后血脑屏障破坏的检测(如药代动力学模型、在脑外伤中诊治及不足)展开阐述。
The destruction of the blood-brain barrier is one of the important pathophysiological changes after traumatic brain injury, which directly affects the course and prognosis of patients with traumatic brain injury. At present, the detection of changes in the blood-brain barrier damage and permeability after traumatic brain injury is receiving more and more attention. The article summarizes the damage of the blood-brain barrier after traumatic brain injury and the importance of its detection, the method of detecting blood-brain barrier disruption and focuses on the detection of the damage to the blood-brain barrier after traumatic brain injury by dynamic contrast enhanced MRI (DCE-MRI) Such as pharmacokinetic model, diagnosis and treatment of brain trauma and inadequate) to elaborate.