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表面增强拉曼光谱(surface-enhanced Raman spectroscopy,SERS)近几年来在物理、化学乃至生物医学方面应用广泛。由于其具有较高的灵敏度、特异性,可用来检测人体血清成分的改变。血清中的各种生物分子包括蛋白质、脂类、核酸等都有各自的特征拉曼光谱,因此不同的拉曼位移、谱带强度及宽度,在分子水平上反映了人体血清中不同的细胞代谢异常。该文对SERS的研究概况以及在多种疾病血清检测中的最新研究进展进行了总结和进一步展望。
Surface-enhanced Raman spectroscopy (SERS) has been widely used in physics, chemistry and even biomedicine in recent years. Because of its high sensitivity, specificity, can be used to detect human serum composition changes. Various biomolecules in serum, including proteins, lipids and nucleic acids, have their own characteristic Raman spectra. Therefore, different Raman shifts, band intensities and widths reflect different cellular metabolism in human serum at the molecular level abnormal. This article summarizes the research progress of SERS and the latest research progress in serum detection of various diseases and further prospects.