论文部分内容阅读
本文在简要概述生物活性多肽对生命科学研究具有十分重要意义的基础上,对生物活性多肽的化学合成作了简短的回顾。化学法合成多肽有液相法和固相法。Fischer在本世纪初开液相法合成多肽的先河;Vigneand用液相法合成出催产素,打开了化学法合成多肽的大门;Merrifield发明多肽的固相合成方法,引起化合法合成多肽方法学上的革命。本文还对我国在化学法合成多肽领域里取得的成就作了介绍。
This article briefly reviews the biological activity of peptides on the life sciences research is of great significance, based on the chemical synthesis of bioactive peptides made a brief review. Chemical synthesis of peptides with liquid and solid phase method. Fischer pioneered liquid phase synthesis of peptides at the turn of the century; Vigneand synthesized oxytocin by liquid phase and opened the door to chemical synthesis of peptides; Merrifield invented the solid-phase synthesis of peptides that led to the chemical synthesis of peptide methodology Revolution. This article also made an introduction on the achievements made by our country in the field of chemical synthesis of peptides.