Meyer 1974年用人肝特异脂蛋白(LSP)免疫家兔,获得了家兔慢性活动性肝炎及肝硬变的模型(1)。其后证明受累的肝细胞表面附有抗-LSP的抗体(2。进一步在慢性活动性肝炎及肝硬变等病人血清中,测到抗-LSP的抗体(3,4。我室对大鼠用人LSP行免疫注射,试图造成免疫肝损伤之模型。结果大鼠均有抗体产生,但未造成模型。材料方法:人LSP按Mc Farlalle(5 方法制备。大鼠30只,分为三组,雌雄各半。第一组腹腔注射人LSP加弗氏完全佐 Meyer immunized rabbits with human liver specific lipoprotein (LSP) in 1974 and obtained a rabbit model of chronic active hepatitis and cirrhosis (1). Subsequently, it was shown that the surface of affected liver cells was accompanied with anti-LSP antibody (2. Further anti-LSP antibody was detected in serum of patients with chronic active hepatitis and cirrhosis) (3, 4. Immune injection with human LSP was used to try to create a model of immune hepatic injury.Results Rats had antibodies but did not cause the model.Materials: Human LSP was prepared by Mc Farlalle (5 methods. Thirty rats, divided into three groups, The first group of intraperitoneal injections LSP Garfield complete adjuvant