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目的：研究肺癌组织中ｃ－ｅｒｂＢ－２、ｎｍ２３蛋白产物的表达情况及其临床意义。方法：应用免疫组织化学ＡＢＣ法，检测９２例手术切除的肺癌组织中ｃ－ｅｒｂＢ－２、ｎｍ２３蛋白产物的表达。结果：９２例肺癌中，ｃ－ｅｒｂＢ－２、ｎｍ２３蛋白产物阳性表达分别为６５例（７０．７％）、３８例（４１．３％）；且ｃ－ｅｒｂＢ－２阳性组与ｎｍ２３阳性组术后转移率分别高于其阴性组。另在４３例肺腺癌中ｃ－ｅｒｂＢ－２阳性组术后５年存活率显著低于其阴性组。结论：ｃ－ｅｒｂＢ－２、ｎｍ２３蛋白产物阳性的肺癌患者易发生术后转移，在肺腺癌中ｃ－ｅｒｂＢ－２表达具负性预后意义
Objective: To study the expression and clinical significance of c-erbB-2 and nm23 protein products in lung cancer. METHODS: Immunohistochemical ABC method was used to detect the expression of c-erbB-2 and nm23 protein products in 92 surgically resected lung cancer tissues. Results: In 92 cases of lung cancer, the positive expression of c-erbB-2 and nm23 protein products were 65 cases (70.7%) and 38 cases (41.3%) respectively; and c-erbB-2 positive group and nm23 positive group were found. The postoperative metastasis rate was higher than that of the negative group. In addition, the 5-year survival rate of the c-erbB-2 positive group in 43 cases of lung adenocarcinoma was significantly lower than that of the negative group. Conclusion: Patients with lung cancer with positive c-erbB-2 and nm23 protein products are prone to postoperative metastasis. The expression of c-erbB-2 in lung adenocarcinoma has a negative prognostic significance.