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目的:加强对侵袭性NK细胞白血病(ANKL)的认识。方法:报告我们新近诊断的1例ANKL患者并进行文献复习。结果:ANKL高发于亚洲人群,其发病与EB病毒感染高度相关;白血病细胞的免疫表型特征为CD+2,sCD-3,CD+3ε,CD+56,TCR重排阴性;临床病程进展快速,预后差;主要应与结外NK/T淋巴瘤和惰性NK细胞淋巴细胞增生性疾患相鉴别。结论:ANKL是一种少见的白血病,遇有疑似病例应及时做免疫学表型、基因重排和病理组织学检测,以明确诊断。
OBJECTIVE: To enhance understanding of aggressive NK cell leukemia (ANKL). METHODS: One of our newly diagnosed ANKL patients was reported and reviewed. Results: The prevalence of ANKL was high in Asian population. The incidence of ANKL was highly correlated with Epstein-Barr virus (EBV) infection. The immunophenotypes of leukemic cells were negative for CD + 2, sCD-3, CD + 3ε, CD + 56 and TCR rearrangements. , Poor prognosis; mainly with extranodal NK / T lymphoma and inert NK cell lymphoproliferative disorders phase identification. Conclusion: ANKL is a rare leukemia. In case of suspected cases, immunological phenotype, gene rearrangement and pathological examination should be done in time to confirm the diagnosis.