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目的:研究正常人在不同海拔地区,血中胃泌素(GAS)、胃动素(MTL)水平的变化,进而探讨人进入高原后机体消化系统的适应性及胃黏膜病变发生的可能机制。方法:选取广州(海拔2m),西宁(海拔2260m),青藏铁路雁石坪(海拔4750m)三个不同海拔高度正常成年男性共62例。分别采血,用放射免疫法测定胃肠激素水平。结果:三个地区正常男性成年人血中GAS的含量分别为25.62ng/L±2.79ng/L、27.37ng/L±5.25ng/L、62.33ng/L±98.64ng/L(与广州比P<0.05,与西宁比P>0.05);MTL的含量为224.12pg/ml±115.36pg/ml、257.61pg/ml±155.70pg/ml、245.22pg/ml±113.72pg/ml,随着海拔升高其血浆水平有变化,但经统计学处理差别无显著性(P>0.05)。结论:随着海拔升高正常成年男性血中GAS和MTL的含量均有明显升高。提示:MTL的含量的变化可能与人体高原胃肠的适应性有密切关系,而GAS的改变与高原胃肠病的高发生率有密切关系。
Objective: To study the changes of blood gastrin (GAS) and motilin (MTL) levels in normal people at different altitudes, and to explore the mechanism of the human digestive system adaptability and gastric mucosal lesions after entering the plateau. Methods: A total of 62 normal adults at three altitudes in Guangzhou (2 m above sea level), Xining (2260 m above sea level), and Yanshiping (4750 m above sea level) on the Qinghai-Tibet Railway. Blood samples were taken and the level of gastrointestinal hormone was measured by radioimmunoassay. Results: The levels of GAS in normal male adults in three regions were 25.62ng / L ± 2.79ng / L, 27.37ng / L ± 5.25ng / L, 62.33ng / L ± 98.64ng / L, respectively <0.05, P <0.05 compared with Xining); MTL content was 224.12 pg / ml ± 115.36 pg / ml, 257.61 pg / ml ± 155.70 pg / ml, 245.22 pg / ml ± 113.72 pg / ml, The plasma level has changed, but the difference was not statistically significant (P> 0.05). Conclusion: The blood levels of GAS and MTL in normal adult men with elevated altitude are significantly increased. It is suggested that the change of MTL content may be closely related to the gastrointestinal adaptation of human plateau, while the change of GAS is closely related to the high incidence of gastrointestinal gastroenteritis.