端粒是真核生物染色体的物理末端结构 ,由富含 G的寡核苷酸 DNA重复序列组成[1 ] 。人类染色体端粒平均长度为 8～14kb,核心序列是 5′TTAGGG3′[2 ,3 ] 。它和相邻的端粒结合蛋白一起具有维持染色体稳定的功能 [4] 。研究表明 ,在结肠癌、Wilms癌、乳腺癌等实体瘤及慢性粒细胞 Telomeres are the physical end structures of eukaryotic chromosomes and are composed of G-rich oligonucleotide DNA repeats [1]. Human chromosome telomere average length of 8 ~ 14kb, the core sequence is 5’TTAGGG3 ’[2, 3]. It together with the adjacent telomere binding protein has the function of maintaining chromosome stability [4]. Research shows that in colon cancer, Wilms cancer, breast cancer and other solid tumors and chronic granulocytes