胆汁淤积是指胆汁分泌的阻滞、抑制或胆汁流的障碍,胆汁到达十二指肠减少,导致胆汁成分在血中蓄积。有关肝内胆汁淤积的发生机制,近几年来有了一些新的认识,为胆汁淤积的诊断、治疗及预后估计提供了理论依据。一、肝内毛细胆管及肝内胆管病损原发性胆汁性肝硬化为肝内胆管病损的典型代表。可见叶间胆管出现增生、小叶间胆管壁上皮细胞呈变性、坏死,上皮细胞间有炎症细胞浸润或出现淋巴细胞增殖,在胆管的周围还可见浆细胞浸润。进而毛细胆管出现结 Cholestasis refers to the block of bile secretion, inhibition or barriers of bile flow, the bile reaches the duodenum decreases, resulting in the accumulation of biliary components in the blood. The pathogenesis of intrahepatic cholestasis in recent years have some new understanding of the diagnosis, treatment and prognosis of cholestasis provides a theoretical basis. First, intrahepatic bile duct and intrahepatic bile duct lesions Primary biliary cirrhosis is a typical representative of intrahepatic bile duct lesions. Visible intrahepatic bile duct hyperplasia, interlobular bile duct epithelial cells were denatured, necrotic, inflammatory cell infiltration between epithelial cells or the emergence of lymphocyte proliferation around the bile duct can also be seen in plasma cell infiltration. And then the bile duct appears knot