Thermosensitive poly[N-vinylacetamide-co-vinylacetate][P(NVA-co-VAc)]hydrogels were prepared via free radical copolymerization from hydrophilic NVA and hydrophobic VAc in the presence of butylenes.bis (N-vinylacetamide)(Bis-NVA)as crosslinker.Scanning electron microscopy(SEM)images reveal that the as-prepared hydrogels were of three-dimensional network with irregular cave structure.The prepared hydrogels with more NVA in the feed swelled faster and the swelling ratio of the hydrogels gradually decreased with temperature increasing from 10℃ to 60℃.The dynamic swelling studies indicate that the swelling process of the hydrogels Was controlled by diffusion of water molecules considered as Fickian-controlled case.The adsorption amount of model drug.sodium salicylate(SS)was higher in the hydrogels containing more NVA units,whose corresponding release could reach equilibrium in about 6 h.