Aim:To investigate the thrombolytic efficacy,ideal dosage and administration ofnative recombinant staphylokinase(r-SAK).Methods:Forty New Zealand rab-bits were randomly assigned into the control,r-SAK low-dose,medial-dose,high-dose,single bolus,allied therapy,recombinant streptokinase(r-SK)and uroki-nase(UK)groups.The right femoral artery thrombosis models were made byballoon injury,and 120 min after the injury,the thrombolytic agents were infusedthrough the rabbits’ parallel-ear vein.Results:(1)2 h after balloon injury,thepulse pressures of the right femoral arteries reduced to 0 or less than 10% of thatof left femoral arteries in all groups;(2)after thrombolytic therapy,the pulsepressures in some of the femoral arteries markedly enhanced to more than 50% ofthat of left femoral arteries;(3)the reopening rates in the r-SAK medial and high-dose groups were significantly higher than that of the control.The reopening rateof the same dose native r-SAK was significant higher than that of UK and r-SK;(4)the patency score of the right femoral arteries tended to be better in the r-SAKmedial and high-dose groups than that of the low-dose group,and the time toreopening in the allied therapy group tended to be shorter.Conclusion:(1)r-SAKhas a definite thrombolytic effect on the femoral artery thrombus of rabbits;(2)single bolus is an effective manner of r-SAK therapy,and r-SAK allied therapywith heparin may shorten the time to recanalization;(3)the efficacy of the samedose native r-SAK was superior to that of r-SK and UK. Aim: To investigate the thrombolytic efficacy, ideal dosage and administration of recombinant staphylokinase (r-SAK). Methods: Forty New Zealand rab-bits were randomly assigned into the control, r-SAK low- dose, medial-dose, high-dose , single bolus, allied therapy, recombinant streptokinase (r-SK) and uroki-nase (UK) groups. The right femoral artery thrombosis models were made byballoon injury, and 120 min after the injury, the thrombolytic agents were infusedthrough the rabbits’ parallel Results: (1) 2 h after balloon injury, the pulse pressures of the right femoral arteries reduced to 0 or less than 10% of that of left femoral arteries in all groups; (2) after thrombolytic therapy, the pulsepressures in some of the femoral arteries markedly enhanced to more than 50% of of left of femoral arteries; (3) the reopening rates in the r-SAK medial and high-dose groups were significantly higher than that of the control. r-SAK was significant higher than that of UK and r-SK; (4) the patency score of the right femoral arteries tended to be better in the r-SAKmedial and high-dose groups than that of the low-dose group, and the time toreopening in the allied therapy group tended to be shorter. Confc: (1) r-SAKhas a definite thrombolytic effect on the femoral artery thrombus of rabbits; (2) single bolus is an effective manner of r-SAK therapy, and r-SAK allied therapy with heparin may shorten the time to recanalization; (3) the efficacy of the samedose native r-SAK was superior to that of r-SK and UK.