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目的:探讨中药护肝方与医用三氧对醋氨酚犬急性中毒性肝衰竭的预防性保护作用.方法:健康杂种犬18只,随机平均分为模型对照组,中药预处理组和医用三氧预处理组.处理15d后各组均进行醋氨酚皮下注射,分别于注射前、注射后24,48,72,96h及7,14d抽血检测肝功能、凝血酶原时间(PT)、血氨(AMMO)、尿素氮(BUN),观察记录全身情况,实验狗死亡时或治疗后存活14d时取肝组织做病理观察.结果:与模型对照组相比,中药组和三氧组的肝组织病理变化程度轻、病灶范围小,肝细胞气球样变和脂肪变性明显.三氧组与中药组谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)、AMMO、PT均显著低于模型对照组(P<0.05或0.01),并且三氧组与中药组相比也有显著差异(P<0.05或0.01).结论:中药护肝方与医用三氧的预防性给药能够有效减轻醋氨酚所致犬急性中毒性肝损害,降低血氨和缩短PT,且医用三氧效果优于护肝方.
Objective: To investigate the preventive effect of traditional Chinese medicine Hugan Fang and medical ozone on acute toxic liver failure induced by acetaminophen in dogs.Methods: Eighteen healthy mixed dogs were randomly divided into model control group, traditional Chinese medicine pretreatment group and medical three Oxygen pretreatment group.After 15 days of treatment, all groups were given acetaminophen subcutaneous injection, respectively, before injection, respectively, at 24,48,72,96h and 7,14d after injection of blood to detect liver function, prothrombin time (PT) AMMO and BUN were observed and recorded in the whole body.The pathological changes of the liver were observed at the death of the experimental dog or 14 days after the treatment.Results Compared with the model control group, The degree of pathological changes in liver tissue was light, the lesion size was small, and the hepatocyte balloon degeneration and steatosis were obvious.Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), AMMO, PT were significantly lower than the model control group (P <0.05 or 0.01), and the three oxygen group compared with the traditional Chinese medicine group also had significant difference (P <0.05 or 0.01) .Conclusion: The traditional Chinese medicine Hugan Fang and medical prophylaxis Medicine can effectively reduce acetaminophen induced acute liver injury in dogs, reduce blood ammonia and shorten the PT, and medical three Liver better than square.