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目的探讨脑苷肌肽治疗新生儿缺氧缺血性脑病(HIE)的疗效。方法将150例HIE新生儿随机分为脑苷肌肽治疗组(A组)、胞二磷胆碱治疗组(B组)、对照组(C组),每组各50例。3组均采用综合治疗。A组在综合治疗基础上加用脑苷肌肽注射液2 mL,1次.d-1,静脉滴注;B组加用胞二磷胆碱注射液125 mg,1次.d-1,静脉滴注。2组均用1个疗程。所有病例由专人每日检查临床表现;分别于出生后3 d内、5~7 d、10~14 d进行新生儿行为神经评分(NBNA);计算各组总有效率并观察各组不良反应。结果 1.A组、B组临床症状恢复时间较C组均明显缩短(Pa<0.05);A组与B组比较差异均无统计学意义(Pa>0.05)。2.A组、B组NBNA均优于C组(Pa<0.05);A组与B组比较差异均无统计学意义(Pa>0.05)。3.A组、B组总有效率均高于C组(P<0.05);A组与B组比较差异无统计学意义(P>0.05)。结论脑苷肌肽可作为治疗新生儿HIE的有效药物之一。
Objective To investigate the therapeutic effect of encephalitoside on neonatal hypoxic-ischemic encephalopathy (HIE). Methods One hundred and fifty newborns with HIE were randomly divided into three groups: group A (treatment group), group B (treatment C), group C (control group C), 50 patients in each group. Three groups were treated with comprehensive treatment. Group A was treated with intravenous injection of 2mg sirolimus injection once a day, on the basis of comprehensive treatment. Group B received 125 mg citicoline injection once a day, Drip. 2 groups were treated with a course of treatment. All cases were examined daily by hand. The neonatal behavioral neurological score (NBNA) was measured within 3 days after birth, 5 to 7 days and 10 to 14 days respectively. The total effective rate was calculated and the adverse reactions of each group were observed. Results 1. The recovery time of clinical symptoms in group A and group B was significantly shorter than that in group C (P <0.05). There was no significant difference between group A and group B (P> 0.05). The NBNA of group A and group B were better than group C (P <0.05). There was no significant difference between group A and group B (Pa> 0.05). The total effective rate of group A and group B was higher than that of group C (P <0.05); There was no significant difference between group A and group B (P> 0.05). Conclusion Cerebroside is one of the effective drugs for the treatment of neonatal HIE.