We study an anisotropic spin cluster of 3 spin S=1/2 particles with antiferromagnetic exchange interaction with non-uniform coupling constants. A time-dependent magnetic field is applied to control the time evolution of the cluster. It is well known that for an odd number og sites a spin cluster qubit can be defined in terms of the ground state doublet. The universal one-qubit logic gate can be constructed from the time evolution operator of the non-autonomous many-body system, and the six basic one-qubit gates can be realized by adjusting the applied time-dependent magnetic field.