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磷酸苯丙哌啉是兼具外周和中枢作用的非成瘾性镇咳药，毒性小，疗效高，目前是临床广泛应用的镇咳药。本文采用高效液相色谱建立了血清中苯丙哌啉的测定方法，并对十名健康志愿者进行了生物利用度测试。结果表明该方法准确性好，重现性高，操作简便易行。直线回归方程Ｙ＝０．
Benproperine phosphate is both non-addictive antitussive peripheral and central role of small toxicity, high efficacy, is currently widely used in clinical cough medicine. In this paper, the determination of benproperine in serum was established by HPLC, and the bioavailability of ten healthy volunteers was tested. The results show that the method is accurate, reproducible and easy to operate. Linear regression equation Y = 0.