论文部分内容阅读
目的:优化尼莫地平肠溶微囊的制备工艺并对其体外释放度进行考察。方法:以纤维醋法酯(CAP)为载体材料,利用单凝聚法,通过正交试验设计,考察囊材与囊芯比、溶解CAP所需磷酸氢二钠pH值及量、span-80量及凝聚剂用量、成囊温度等因素对微囊包封率及载药量的影响,初步筛选出最佳处方工艺条件。此外,还建立了紫外分光光度法测定微囊的载药量与包封率,考查其体外释放度。结果:所得微囊外观圆整,测得平均包封率为80.4%,平均载药量为41.7%。结论:该制备方法简单易行,所制得的微囊肠溶效果理想。
Objective: To optimize the preparation process of nimodipine enteric microcapsules and investigate its in vitro release. Methods: Using CAP as carrier material, single-coacervation method was used to investigate the relationship between the ratio of capsule material to capsule core and the pH value and amount of disodium hydrogen phosphate required to dissolve CAP, span-80 And the amount of coagulant, encapsulation temperature and other factors on the encapsulation efficiency of microencapsulation and drug loading, the initial screening of the best prescription process conditions. In addition, UV-spectrophotometry was also established to determine the drug-loading capacity and encapsulation efficiency of microcapsules. Results: The appearance of the obtained microcapsules was rounded. The average encapsulation efficiency was 80.4% and the average drug loading was 41.7%. Conclusion: The preparation method is simple and easy, and the prepared microcapsules have good enteric effect.