致命性拉沙热最重要的病变在肝脏,病死率约为20%,目前对其发病机理了解甚少。虽然患者的多器官感染十分明显,但组织学上却未见足以导致死亡的病理变化。作者在5年中对19例拉沙热患者进行了死后肝活检,发现在这些致死性病例中有严重、广泛及进展性拉沙病毒性肝炎。作者在 The most important fatal case of Lassa fever in the liver, the case fatality rate of about 20%, at present little understanding of its pathogenesis. Although multiple organ infections were evident in patients, no histological changes were found that were sufficient to cause death. The authors performed post-mortem liver biopsy on 19 patients with Lassa fever in 5 years and found severe, widespread and aggressive Lassa viral hepatitis in these fatal cases. The author is here