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多巴胺D3受体(dopam ine D3 receptor,DRD3)基因位于人类第3号染色体上[1],主要在大脑的边缘系统表达,被认为是与精神症状有关的重要候选基因之一[2],其功能可能是影响第二信使系统,对腺苷酸环化酶有抑制作用。在DRD3基因座的第一外显子上存在一个Ser9G ly(第9密码子由丝氨酸变
The dopamine D3 receptor (DRD3) gene is located on human chromosome 3 [1] and is mainly expressed in the limbic system of the brain. It is considered as one of the important candidate genes related to psychotic symptoms [2] Function may affect the second messenger system, adenylyl cyclase inhibition. There is a Ser9Gly at the first exon of the DRD3 locus (the 9th codon is changed from serine