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[目的]探讨 hepcidin 在判定慢性肾脏病(CKD)不同分期患者机体铁贮存和功能性缺铁方面的价值以及对促红细胞生成素(EPO)治疗反应的影响.[方法]检测70例 CKD 不同分期患者血清 Hepcidin 水平以及血液铁代谢指标、高敏 C 反应蛋白(hsCRP)和相关生化指标.[结果]患者血清 Hepcidin 水平随着肾小球滤过功能减退,逐渐升高,CKD 5期血透组 Hepcidin 水平最高(120.81±6.65μg/L)( P < 0.001).血透组Hepcidin 水平与血清铁蛋白和转铁蛋白饱和度呈正相关.在不考虑 CKD 分期的情况下,血清 hepcidin 水平与 hsCRP 呈正相关,与肾小球滤过率(GFR),外周红细胞计数和红细胞压积呈负相关.在血透组 A 、B 亚组中,EPO ≥9000 IU 的 A 组血清 hepcidin 水平高于 EPO <9000 IU 的 B 组( P < 0.001).[结论]慢性肾脏病时随着 GFR 的下降,血清 hepcidin 水平增加,这可能与肾脏清除 hepcidin 减少和 CKD 时存在微炎症状态有关.血清 hepcidin 升高引起功能性铁缺乏,贮存铁利用障碍和 EPO 低反应,最终使贫血难以纠正.“,”Objective] To explore the value of the detection of serum hepcidin in evaluating iron storage and deficiency in patients with different stages of chronic kidney disease (CKD) and its effect on the response to erythropoietin(EPO) treatment .[Methods] Serum hepcidin ,iron metabolic index ,high sensitive C‐reactive protein(hsCRP) and related biochemical indicators of 70 patients with different stages of CKD were detected .[Results]Serum hepcidin gradually increased with the declining of glomerular filtration rate (GFR) .Serum hepcidin in hemodialysis group at CKD5 stage was the highest(120 .81 ± 6 .65 μg/L)( P < 0 .001) .Serum hep‐cidin in hemodialysis group was correlated positively with serum ferritin and transferin saturation .In spite of the stage of CKD ,serum hepcidin was correlated positively with hsCRP and negatively with GFR ,periphery red blood cell count and hematocrit .In hemodialysis group ,serum hepcidin in subgroup A with EPO ≥ 9000IU was higher than that in subgroup B with EPO < 9000IU ( P < 0 .001) .[Conclusion] Serum hepcidin level in CKD patients increases with the declining of GFR .The increasing of serum hepcidin may be correlated with the decreased hepcidin clearance and microinflammation status in CKD patients .The rising level of serum hep‐cidin can induce functional iron deficiency ,the disorder of stored iron utilization and EPO hyporesponsiveness , subsequently result in refractoriness to anemia therapy .