目的 :动态监测实验性脑出血大鼠血肿周边及下丘脑去甲肾上腺素 (NE)含量的变化规律并探讨其机制。方法 :采用胶原酶和肝素联合注入尾状核的方法建立大鼠脑出血模型 ,利用高效液相电化学法测定出血前及出血后 0 .5、6、12、2 4、48和 72小时各时间点血肿周边及下丘脑的 NE含量。结果 :大鼠脑出血后 30分钟血肿周边及下丘脑 NE含量开始同步升高 ,并于 2 4小时达峰值〔分别为 (5 5 5 .18± 2 0 .31) ng/ g和 (7846 .16±416 .12 ) ng/ g〕,48小时开始回落。结论 :大鼠脑出血过程中 ,脑内各部位去甲肾上腺素聚集 ,可使神经细胞过度兴奋 ,使局部脑血流进一步减少 ,并能影响神经内分泌功能 ,最终加重神经细胞损害。 OBJECTIVE: To dynamically monitor the changes of norepinephrine (NE) content in perihematoma and hypothalamus of experimental intracerebral hemorrhage in rats and to explore its mechanism. Methods: The model of intracerebral hemorrhage was established by injecting collagenase and heparin into the caudate nucleus. The rats were sacrificed at 0.5, 6, 12, 2, 48, and 72 h after hemorrhage by high performance liquid electrochemistry Time points around the hematoma and hypothalamus NE content. RESULTS: NE concentrations in the perihematoma and hypothalamus began to rise synchronously at 30 min after intracerebral hemorrhage and peaked at 24 h [(55.518 ± 0.203) ng / g and (7846, respectively]. 16 ± 416 .12) ng / g〕, 48 hours began to fall. Conclusion: During the process of intracerebral hemorrhage, norepinephrine accumulates in various parts of the brain, which can excite nerve cells and further reduce the local cerebral blood flow, and can affect neuroendocrine function and finally aggravate neuronal damage.