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目的分析HIV-1抗体阳性吸毒者的WB带型,了解惠州市男性吸毒人群WB带型的分布特征。方法对本实验室2007～2010年的HIV-1抗体确证检测阳性男性吸毒者的WB带型进行统计分析。结果 113份HIV-1抗体确证检测阳性男性吸毒者的WB带型中,gp160、gp120带型的出现率均在100%,p66、p51、gp41、p31、p24带型的出现率均在96%以上,p55,p17带型的出现率分别为71.68%和80.53%;WB全带型出现率为59.30%(67/113);不同年龄组带型差异无统计学意义。结论抗env和gag基因编码蛋白的抗体gp160、gp120、gp41、p24阳性率高,是确证HIV-1感染的必备条件;惠州市的HIV亚型、传播途径和WB带型之间的关系有待进一步的调查和研究。
Objective To analyze the WB bands of HIV-1 positive drug users and find out the distribution characteristics of WB bands in male drug users in Huizhou. Methods We performed a statistical analysis on the WB bands of positive male HIV-1 patients confirmed by HIV-1 antibody in our laboratory from 2007 to 2010. Results The positive rates of gp160 and gp120 in WB bands of 113 male HIV-1 positive test-positive men were both 100%. The prevalence of p66, p51, gp41, p31 and p24 was 96% The incidence rates of p55 and p17 were 71.68% and 80.53%, respectively. The incidence of WB full-band was 59.30% (67/113). There was no significant difference between the different age groups. Conclusions The positive rates of gp160, gp120, gp41 and p24, which encode proteins of anti-env and gag genes, are the necessary conditions to confirm HIV-1 infection. The relationship between HIV subtypes, transmission routes and WB types in Huizhou Further investigation and research.