本文报道黄酮类化合物对离体血管平滑肌的作用,并讨论有关其解痉和舒血管方面的构-效关系。作者用离体大白鼠的主动脉肌条作标本,以苯肾上腺素(0.5μM)诱发痉挛,研究一系列黄酮类化合物甙元的解痉作用。下表中I_(50)表示引起主动脉松弛50%所需的药物浓度,n为实验次数。结果表明,取代类型和 This article reports on the effects of flavonoids on isolated vascular smooth muscle and discusses the structure-activity relationship in terms of their antispasmodic and vasodilating effects. The authors used the aortic strips of isolated rats as specimens and induced convulsions with phenylephrine (0.5 μM) to study the antispasmodic effect of a series of flavonoid aglycone. I_ (50) in the table below indicates the drug concentration required to cause 50% relaxation of the aorta, and n is the number of experiments. The result shows that instead of type and