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目的：探讨左旋氨氯地平联合培哚普利治疗中青年原发性高血压患者的临床疗效和安全性。方法将72例中青年原发性高血压患者按照随机数字表法分为观察组和对照组，每组43例，均口服左旋氨氯地平治疗，观察组在此基础上联合培哚普利治疗，观察1个月。观察治疗前后两组血压、心率的变化，依据疗效及血压达标判定标准评定两组临床疗效及血压达标率，随时记录治疗过程中出现的不良反应。结果治疗后两组收缩压、舒张压和心率均较治疗前显著下降（P＜0．01），且观察组各项指标均显著低于对照组（P＜0．01）。观察组总有效率为97．7％、血压达标率为81．4％，对照组分别为79．1％、44．1％，观察组总有效率、血压达标率显著高于对照组（P＜0．01）。两组不良反应较轻微，发生率比较差异无显著性（P＞0．05）。结论左旋氨氯地平联合培哚普利治疗中青年原发性高血压患者具有协同增效作用，疗效显著，安全性高。“,”Objective To explore the efficacy and safety of levoamlodipine plus perindopril in the treatment of young and middle‐aged essential hypertension .Methods Seventy‐two young and middle‐aged patients with essential hypertension were randomly divided into observation and control group of 36 ones each ,both groups took orally levoamlodipine ,and on this basis observation group was plus perindopril for 1 month . Pre‐and post‐treatment BP and HR changes of both groups were observed ,efficacies and BP normalized rates assessed according to efficacy and judgement criterion of BP standardization ,and adverse reactions occurred during treatment recorded at any time .Results Systolic and diastolic pressures as well as HRs of both groups lowered more significantly after treatment (P<0 .01) ,all indexes were significantly lower in observation than control group (P< 0 .01) .Total effective and BP normalized were respectively 97 .7%and 81 .4% in observation and 79 .1% and 44 .1% in control group ,the former significantly higher than the latter (P0 .05) .Conclusion Levoamlodipine plus perindopril has a synergism ,evident effect and higher safety in the treatment of young and middle‐aged patients with essential hypertension .