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目的探讨儿童感染性噬血细胞综合征病原、临床特点、治疗及预后。方法对22例儿童感染相关性噬血细胞综合征的临床资料进行回顾性分析。结果10例EB病毒感染,CMV病毒感染2例,支原体感染5例,肺炎链球菌感染3例,单纯疱疹病毒感染1例,微小病毒感染1例。经积极治疗原发病同时给予免疫调节并加强支持治疗,死亡4例,好转10例,治愈6例,放弃治疗2例。结论感染相关性噬血细胞综合征EB病毒感染多见,其次为支原体感染,及早积极治疗原发感染预后良好,病情轻者、细菌及支原体感染者不需要化疗,病死率低,EB病毒感染,病情重预后差。
Objective To investigate the pathogens, clinical features, treatment and prognosis of children with infectious hemophagocytic syndrome. Methods The clinical data of 22 cases of children with associated hemophagocytic syndrome were retrospectively analyzed. Results 10 cases of Epstein-Barr virus infection, 2 cases of CMV virus infection, 5 cases of mycoplasma infection, 3 cases of pneumococcal infection, herpes simplex virus infection in 1 case, 1 case of parvovirus infection. Active treatment of primary disease while giving immune regulation and supportive care, death in 4 cases, improved in 10 cases, 6 cases cured, give up treatment in 2 cases. Conclusions Infection-associated hemophagocytic syndrome EBV infection is more common, followed by mycoplasma infection, and early positive treatment of primary infection with a good prognosis, mild disease, bacterial and mycoplasma infection without chemotherapy, low mortality, Epstein-Barr virus infection, the disease Poor prognosis.