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目的探讨合并或不合并非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)的2型糖尿病(type 2 diabetes,T2DM)人群中的早期糖尿病肾病发病率并初步探讨其机制。方法 232名符合入组标准的T2DM患者,分为单纯T2DM组(对照组)与合并NAFLD的T2DM组(实验组),检测患者肝功能、血脂、尿微量白蛋白(urinary albumin,mAlb)、HOMA-IR、高敏c反应蛋白(CRP)并进行分析。结果实验组患者mAlb阳性率显著高于对照组(P<0.05);实验组CRP、HOMA-IR等生化指标也高于对照组(P<0.01或者P<0.05)。结论合并NAFLD的T2DM患者更加容易患糖尿病肾病;胰岛素抵抗和CRP可能参与了其发生机制。
Objective To investigate the incidence of early diabetic nephropathy in type 2 diabetes (T2DM) with or without non-alcoholic fatty liver disease (NAFLD) and to explore its mechanism. Methods Totally 232 T2DM patients were enrolled in this study. They were divided into two groups: T2DM group (control group) and T2DM group (experimental group) with NAFLD. Liver function, blood lipid, urinary albumin (mAlb), HOMA -IR, high-sensitivity c-reactive protein (CRP) and analyzed. Results The positive rate of mAlb in experimental group was significantly higher than that in control group (P <0.05). The biochemical indexes such as CRP and HOMA-IR in experimental group were also higher than those in control group (P <0.01 or P <0.05). Conclusion T2DM patients with NAFLD are more susceptible to diabetic nephropathy. Insulin resistance and CRP may be involved in the pathogenesis of T2DM.