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近几年来,异菸肼(以下簡称INH)在人体內的代謝过程成为許多学者研究的課題。諸如血及尿中代謝物的分析,血、体液及尿中浓度的测定,代謝的速度以及代謝快慢与临床疗效的关系等等問題,皆有不少文献报道。本文择其主要者綜述之。 1952年De Ritter氏发現INH在人体内可代謝为异菸酸,1953年Hughes氏及1954年Makino氏又发現INH之另一代謝产物——乙醯INH(1-isonicotiny1-2:acetyl
In recent years, isoniazid (hereinafter referred to as INH) in the human body metabolism process has become the subject of many scholars. Such as blood and urine metabolites analysis, blood, body fluids and urine concentration determination, the rate of metabolism and metabolic rate and the relationship between clinical efficacy and so on, there are many literatures. This article selected the main summary. In 1952, De Ritter’s found that INH can be metabolized to isonicotinic acid in the human body. In 1953, Hughes’s and Makino’s discovered another INH metabolite, 1-isonicotiny1-2: acetyl