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目的探讨芪参颗粒联合运动疗法对心力衰竭大鼠心功能和左室重构的影响。方法采用冠脉左前降支(IAD)结扎法复制SD大鼠急性心肌梗死后心力衰竭模型,术后4周末,将动物随机分为模型组、芪参颗粒组、芪参颗粒联合运动疗法组及单纯运动疗法组,治疗后第8周末进行超声心动检测和心脏组织形态学观察。结果与假手术组相比,模型组大鼠左心室射血分数(IVEF)显著下降,左室舒张末期内径(IVEDd)及左室收缩末期内径(LVEDs)显著增加(P<0.01),染色示左心室短轴缩短率(LVFS)显著缩短(P<0.01);左室重量指数、心脏重量指数、室腔周长、室腔面积均显著增加(P<0.01);左心室重构病理特征显著。与模型组相比,芪参颗粒治疗组及芪参颗粒联合运动疗法组大鼠左室射血分数、左室短轴缩短率等指标均显著下降(P<0.05或P<0.01),室腔周长及面积显著缩小(P<0.01),且病理变化有所减轻。结论芪参颗粒联合运动疗法能够改善急性心肌梗死后心力衰竭大鼠心功能,延缓左室重构的发生和发展。
Objective To investigate the effect of Qiguan Granule combined exercise therapy on cardiac function and left ventricular remodeling in rats with heart failure. Methods The left anterior descending coronary artery (IAD) ligation was used to duplicate the model of heart failure after acute myocardial infarction in SD rats. At the end of the fourth week after operation, the animals were randomly divided into model group, Qishen Granule Group, Qishen Granule combined with exercise therapy group, Simple exercise therapy group, 8 weeks after treatment echocardiography and cardiac histological observation. Results Compared with the sham-operation group, the left ventricular ejection fraction (IVEF), the left ventricular end-diastolic diameter (IVEDd) and the left ventricular end-systolic diameter (LVEDs) in the model group were significantly increased (P <0.01) The left ventricular fractional shortening (LVFS) was significantly shortened (P <0.01). The left ventricular mass index, cardiac mass index, chamber circumference and chamber area were significantly increased (P <0.01) . Compared with the model group, the indexes of left ventricular ejection fraction and shortening rate of shortening of left ventricle of rats in Qishen Granule treatment group and Qishen Granule combined exercise group were significantly decreased (P <0.05 or P <0.01) Perimeter and area were significantly reduced (P <0.01), and pathological changes have eased. Conclusion Qishen granule combined exercise therapy can improve heart function and delay the occurrence and development of left ventricular remodeling in rats with heart failure after acute myocardial infarction.