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取新西兰兔１５只，造成双侧桡骨骨干８ｍｍ骨缺损。一侧采用１ｍｍ厚壳多糖膜管包绕成管室＇状，两端各超越骨断端２ｍｍ；另一侧作为空白对照组。术后６周，对愈合情况采用ｘ线及组织学检查，空白组均呈骨不连接，膜管包绕组，在其表面形成薄形、连续性外骨痂，膜管内形成少量骨痂。结果表明，壳多糖对骨组织修复有传导成骨作用。
Take 15 New Zealand rabbits, resulting in bilateral 8mm bone defect radius. One side of 1mm thick film coated with polysaccharide tube into the tube ’like shape, both ends beyond the fracture ends 2mm; the other side as a blank control group. At 6 weeks after operation, the healing condition was evaluated by x-ray and histological examination. The blank group was not connected with the bone and the wound tube was wrapped. A thin and continuous outer callus was formed on the surface of the wound. A small amount of callus was formed in the wound. The results showed that chitosan conducts osteogenesis on the repair of bone tissue.