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我们用ＥＢ病毒转化法从免疫性不育或流产患者的淋巴细胞中制备了一批抗精子和抗附睾的人单克隆抗体。抗精子抗体与全精子、精子头、精子尾、赤道部或核后部反应；抗附睾抗体与附睾基细胞或纤毛区反应。这些来源于不育患者淋巴细胞的抗体具有抗生育效应的可能性较大，对人体具有副作用的可能性相对较小。其中抗附睾基细胞抗体的作用区段与精子在附睾内成熟的区段相一致，这种抗体对基细胞的功能及其在生殖过程中的作用均有特殊的研究价值。
We generated a panel of human anti-sperm and anti-epididymal human monoclonal antibodies from Epstein-Barr virus transformed lymphocytes from immunocompromised or aborted patients. Anti-sperm antibodies react with whole spermatozoa, sperm heads, sperm tail, equatorial part or nucleus retroflexus; anti-epididymis antibodies react with epididymal cells or cilia area. Antibodies derived from lymphocytes of infertile patients are more likely to have anti-fertility effects and are less likely to have side effects on the human body. Which anti-epididymal cell antibodies section and sperm in the epididymis mature section consistent, the antibody on the cell function and its role in the reproductive process has a special research value.