以前的动物研究已经证明白细胞介素12((IL-12)具有抑制各种活体肿瘤细胞生长的作用,但对试管肿瘤细胞无直接作用。然而用T细胞缺陷小鼠进行试验,IL-12的抗肿瘤活性并未完全消失,说明与人们估计的T细胞调节作用无关。观察结果显示IL-12可能具有抗血管生成作用,从而抑制活体肿瘤的生长。 本研究的目标是研究IL-12的抗血管生长特性。方法是在小鼠用碱性成纤维细胞因 Previous animal studies have demonstrated that interleukin 12 (IL-12) has the effect of inhibiting the growth of various tumor cells in vivo, but has no direct effect on vitro tumor cells. However, it was tested in T-cell deficient mice, IL-12 The anti-tumor activity has not completely disappeared, indicating that it is not related to the estimated T cell regulation. Observations have shown that IL-12 may have anti-angiogenic effects, thus inhibiting the growth of living tumors. The goal of this study is to study the resistance of IL-12. Vascular growth characteristics.Methods are used in mice with basic fibroblasts