在动物中诱发膀胱肿瘤,是研究人类膀胱肿瘤病因、病理及治疗等问题的有效途径。Oyasa等认为;理想的膀胱肿瘤动物模型应具备几个条件:①移行上皮性肿瘤;②致癌物或抗癌物易于反复灌入;并能充分与膀胱粘膜相接触;③不易形成结石或感染。在文献中,根据制作方法的不同,膀胱肿瘤动物模型大致有四种类型:①自发型,主要来源于某些有患膀胱肿瘤的遗传倾向的同种系鼠类;②病毒诱导 Inducing bladder tumors in animals is an effective way to study the etiology, pathology and treatment of human bladder cancer. Oyasa and other think; ideal bladder tumor animal models should have several conditions: ① transitional epithelial tumors; ② carcinogens or anti-cancer substances easily repeated infusion; and fully contact with the bladder mucosa; ③ not easy to form stones or infections. In the literature, there are roughly four types of animal models of bladder cancer depending on the method of manufacture: (1) spontaneous type, mainly from some of the same type of mice with genetic predisposition to bladder cancer; (2) viral induction