缺氧诱导因子 1是在体内广泛存在的核内转录因子 ,有两个亚基。HIF 1是细胞在缺氧条件下产生的核蛋白 ,它与靶基因结合后可调节多种基因如内皮素、血管内皮生长因子、诱导型一氧化氮合酶等的表达 ,促进机体对缺氧产生一系列的适应反应。其活性的维持对心脏的发育以及对心肌在缺血缺氧性疾病中的代偿起着重要作用。对HIF 1与心脏缺氧代偿关系的研究可为治疗心脏疾病提供新的途径 Hypoxia-inducible factor 1 is a nuclear transcription factor widely present in the body and has two subunits. HIF 1 is a nuclear protein produced by cells under hypoxic conditions. When combined with a target gene, HIF 1 can regulate the expression of many genes such as endothelin, vascular endothelial growth factor and inducible nitric oxide synthase, and promote the hypoxia Produce a series of adaptive response. The maintenance of its activity plays an important role in the development of the heart and compensates for myocardial ischemia and hypoxia. The study on the relationship between HIF-1 and cardiac hypoxia may provide a new way to treat heart disease