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目的 对过敏康Ⅱ号胶囊治疗男性免疫性不育进行了研究 ,并对其作用机制进行了初步探讨。方法 对NIH雄鼠采用主动免疫法建立血清抗精子抗体 (AsAb)阳性动物模型 ,分别选用醋酸泼尼松以及具有益气固表、凉血消风作用的过敏康Ⅱ号胶囊 ,于建模的同时灌胃给药 ,观察药物对NIH雄鼠血清AsAb的影响。结果 过敏康Ⅱ号 3个剂量组血清AsAb吸光值均明显低于模型组 (P<0 0 1)。结论 过敏康Ⅱ号胶囊确有抑制AsAb产生的作用 ,为临床治疗AsAb阳性免疫性不育患者提供了实验依据
Objective To study the effect of Allergy Capsule II on the treatment of male infertility in males and to discuss the mechanism of action. METHODS: Male Sprague-Dawley (NIH) male mice were established with an active anti-serum antibody (AsAb) positive animal model. Prednisone acetate and allergic Kang II capsules with Yiqi Gubiao and Liangxuexiaofeng were used for modeling. At the same time, intragastric administration was performed to observe the effect of drugs on serum AsAb of NIH male rats. Results Absorbance value of serum AsAb in Allergic II group was significantly lower than that in model group (P<0 01). Conclusion Allergy Capsule II can inhibit the production of AsAb, which provides experimental basis for clinical treatment of AsAb positive immune infertility patients.