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用萘普生(Naproxen)治疗16例小儿白血病和淋巴瘤的发热,年龄16个月-17岁,女10,男6,体温>38.3℃,WBC 400/μl-33.3×10~3/μl,中性粒细胞绝对计数0-4514/μl。给药指征:(1)体温>38.3℃,(2)发热持续72小时,(3)无临床及实验室所见感染的证据,(4)阴性胸片结果。14/16例符合上述指征者,皆于萘普生治疗开始后6小时退热,用量,7.5mg/kg/次,12小时1次,连续7天。2例无效者,均有感染的阳性培养结果。讨论:Cashman等研究了萘普生的退热效果并与阿斯匹林及一种安慰剂进行比较,结果萘普生比阿斯匹林有效。本品为非固醇类抗炎药,用药不过7天时,未见任何副作用。有认为其治疗合并症包括胃肠出血(尤对原有消化性溃疡者);SGPT变化见于不足1%病人;血液学毒性有嗜酸红细胞增多、粒细胞减少、白细胞及血小板减少。本品作用机理也许是通
Treatment of 16 pediatric leukemias and lymphomas with naproxen, aged 16 months to 17 years, female 10, male 6, body temperature> 38.3 ° C, WBC 400 / μl to 33.3 × 10 -3 / μl, Absolute neutrophil count 0-4514 / μl. Administration indications: (1) body temperature> 38.3 ℃, (2) fever sustained for 72 hours, (3) no clinical and laboratory evidence of infection, (4) negative chest radiography results. 14/16 patients who met the above indications were treated with naproxen 6 hours after the start of fever, the amount of 7.5mg / kg / 12 times for 7 days. 2 cases were ineffective, have positive results of infection culture. Discussion: Cashman et al. Studied the antipyretic effect of naproxen and compared it to aspirin and a placebo, with naproxen being more effective than aspirin. This product is non-steroidal anti-inflammatory drugs, medication, but 7 days, no any side effects. There are considered that the treatment of complications, including gastrointestinal bleeding (especially for the original peptic ulcer); SGPT changes found in less than 1% of patients; hematologic toxicity eosinophilia, neutropenia, leukopenia and thrombocytopenia. This product may be the mechanism of action