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β受体与腺苷环化酶(AC)是两种不同的蛋白,β受体通过G蛋白与AC相耦联。β受体有高低亲和力两种状态。鸟核苷酸对受体高低亲和力的转换和AC活性起调节作用。受体周围生物活性物质的浓度与受体数目间呈负相关。细胞与活性物质长期接触后,出现去敏现象,此时受体数目下降,形成高亲和力状态的能力受损。肾上腺素受体受各种因素的影响,在某些病理状态时受体数目发生改变。监测药物治疗过程中受体的变化,对药物疗效、药物耐受(去敏)和戒断症状(增敏)的解释提供了新的依据,这给诊断学和治疗学开辟了一个新领域。
The beta receptor and adenosine cyclase (AC) are two distinct proteins, and the beta receptor is coupled to the AC by the G protein. β receptors have high and low affinity of two states. Bird nucleotides have low and high affinity receptors for the conversion and AC activity play a regulatory role. There was a negative correlation between the concentration of bioactive material around the receptor and the number of receptors. Long-term contact with cells and active substances, there desensitization phenomenon, when the number of receptors decreased, the ability to form a high affinity state impaired. Adrenergic receptors are affected by a variety of factors, with changes in the number of receptors in certain pathologies. Monitoring the changes of the receptors during drug treatment provides new evidence for the explanation of drug efficacy, drug resistance (desensitization) and withdrawal symptoms (sensitization), opening up a new area for diagnostics and therapeutics.