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为测定西地那非局部应用对愈合慢性肛裂的功效,Moghimi M等人进行了一项前瞻性、随机双盲研究,研究入选61例症状持续四周的慢性肛裂患者,随机给予西地那非或安慰剂治疗。西地那非31例患者给予10%西地那非霜0.75ml,每日3次经肛门给药;对照组30例患者使用用安慰剂,共用7d;患者如仍有症状则再用药2d。所有病例随访2-3个月。肛裂愈合或发生并发症则结束试验。结果显示,治疗组肛裂愈合率显著
To determine the efficacy of topical sildenafil use in the treatment of chronic anal fissure, Moghimi M et al. Conducted a prospective, randomized, double-blind study of 61 patients with chronic anal fissure that lasted for four weeks and were randomized to cedilanone Non-or placebo treatment. Thirty-one patients in sildenafil received 0.75ml of 10% sildenafil, and received anal analgesia three times a day. Thirty patients in the control group received placebo for 7 days. Patients were treated for 2 days if they were still having symptoms. All cases were followed up for 2-3 months. Anal fissure healing or complications will end the trial. The results show that the treatment group anal fissure healing rate significantly