Objective:To observe the relationship between the grade of constriction and blood pressures of the rabbit femoral artery, and construct an animal model of the femoral artery thrombosis by balloon injury. Methods:In 10 New Zealand rabbits, the right femoral arteries were gradually narrowed by nylon thread till complete occlusion. The grade of constriction and corresponding femoral artery blood pressures were recorded. Then a 2.5 mm×20.0 mm balloon was put into the right femoral artery to induce endothelial denudation. The femoral artery blood pressure was monitored after the balloon was pulled out. Blood samples were collected to determine the platelet quantity pre and post balloon injury. The femoral artery angiography was performed in a few rabbits before and after the injury. All the injured arteries were segmented for the pathological study at last. Results:①Systolic blood pressure and pulse pressure dropped in the rabbit femoral artery while the artery was constricted by 90%. Moreover, the pulse pressure reduced to zero when the artery was completely occluded, with a simultaneous drop of the diastolic blood pressure and mean blood pressure. ②The systolic blood pressure and pulse pressure of femoral artery dropped significantly 5 minutes later of the balloon injury, and the pulse pressure reduced to zero 90 minutes after the injury, with a significant decrease of the diastolic blood pressure and mean blood pressure. ③Both the femoral artery angiography and histological examination showed that the thrombus was created in the femoral artery after balloon injury and the arterial lumen was occluded completely. ④The quantity of platelet significantly decreased 2 hours later of the balloon injury. Conclusion:Balloon injury could make a stable and reliable thrombus model of the femoral artery in rabbits, which will be very useful to the pharmacokinetic and pharmacodynamic study of the thrombolytic agents. Methods: In 10 New Zealand rabbits, the right femoral arteries were gradually narrowed by The thread of complete occlusion. The grade of constriction and corresponding femoral artery blood pressures were recorded. Then a 2.5 mm × 20.0 mm balloon was put into the right femoral artery to induce endothelial denudation. The femoral artery blood pressure was monitored after the balloon was pulled out. Blood samples were collected to determine the platelet quantity pre and post balloon injury. The femoral artery angiography was performed in a few rabbits before and after the injury. All the injured arteries were segmented for the pathological study at last. Results: ① Systolic blood pressure and pulse pressure dropped in the rabbit femoral artery while the artery was constricted by 90% The pulse pressure reduced to zero when the artery was completely occluded, with a simultaneous drop of the diastolic blood pressure and mean blood pressure. and the pulse pressure reduced to zero 90 minutes after the injury, with a significant decrease of the diastolic blood pressure and mean blood pressure. ④The quantity of platelet significantly decreased 2 hours later of the balloon injury. Conclusion: Balloon injury could make a stable and reliable thrombus model of the femoral artery in rabbits, which will be very useful to the pharmacokinetic and pharmacodynamic study of the thrombolytic agents