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目的:对杭州市萧山区疑似人乳头瘤病毒(HPV)感染的6868例妇女进行调查,研究基因亚型分布状况,为预防HPV感染和宫颈癌防治提供依据。方法:利用DNA杂交技术检测妇科门诊样本并进行基因分型。结果:6868例样本中,HPV感染者1570例,阳性率22.68%,检出高危基因型(HPV16、18、31、33、35、39、45、51、52、53、56、58、59、66、68、73、83和MM4型)1316例,约占感染者的83.82%;低危型(HPV6、11、42、43和44型)254例。23个亚型中16型最多,其次为52型。1094例为单一型基因,占HPV感染者的69.68%。>25岁各年龄段间感染率没有显著性差异。结论:高危亚型、单一感染为常见类型,HPV16为主要感染亚型。
Objective: To investigate the distribution of the subgenotypes in 6868 women suspected of human papillomavirus (HPV) infection in Xiaoshan district of Hangzhou City, and to provide basis for prevention of HPV infection and prevention and treatment of cervical cancer. Methods: Gynecological clinic samples were detected by DNA hybridization and genotyped. Results: Of the 6868 samples, 1570 were HPV-infected, the positive rate was 22.68%. High-risk genotypes were detected (HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66,68,73,83 and MM4 type) 1316 cases, accounting for 83.82% of infected persons; low-risk type (HPV6,11,42,43 and 44 type) 254 cases. Of the 23 subtypes, 16 were the largest, followed by 52. 1094 cases of a single type of gene, accounting for 69.68% of HPV infected. There was no significant difference in infection rates among all age groups> 25 years old. Conclusion: High-risk subtypes, single infection is a common type, HPV16 is the main subtype of infection.