论文部分内容阅读
静脉注射作用迅速的降压药如二氮嗪和硝普钠治疗高血压急症简便而安全,但这两个药都有副作用,对许多中等度到重度的高血压病人以及有并发症的病人不适用,对他们来说,很需要几小时内就能降压而无副作用的口服药物。药物动力学研究表明,可乐宁符合这些性质。参加本试验治疗者皆为有合并症的高血压病人。病人首次口服可乐宁0.1或0.2 mg,随后每1小时服0.1 mg,直至明显降压或直至服完全量0.5mg 为止。结果15例中,12例(80%)平均血压降低33±3 mmHg,另3例因其它理由未计算在内。平均于服药后2.25小时开始降压。12例中4例仅需0.2mg 降压,其余2例需0.3mg,2例需0.4mg,3例需0.5mg,1例需0.7mg。体位性低血压少见,仅1
Intravenous rapid antihypertensive drugs such as diazoxide and sodium nitroprusside are simple and safe for the treatment of hypertensive emergency, but both drugs have side effects and are not effective in many patients with moderate to severe hypertension and with complications For them, it takes a lot of oral medication for them to be able to take their blood pressure down within a few hours without any side effects. Pharmacokinetic studies have shown that clonidine meets these properties. Participants in this trial are all patients with complications of hypertension. For the first time, patients took clonidine 0.1 or 0.2 mg, followed by 0.1 mg every 1 hour until markedly depressurized or until a full dose of 0.5 mg was given. Results In 15 cases, the average blood pressure of 12 patients (80%) was reduced by 33 ± 3 mmHg, and the other 3 patients were not included for other reasons. On average 2.25 hours after taking the blood pressure. Of the 12 patients, only 0.2 mg of blood pressure was required in 4 patients, 0.3 mg in the other 2 patients, 0.4 mg in 2 patients, 0.5 mg in 3 patients and 0.7 mg in 1 patient. Postural hypotension rare, only 1