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为了解地红霉素体内抗菌效果,用小鼠作地红霉素与红霉素体内保护试验。结果为:地红霉素对金黄色葡萄球菌、肺炎链球菌、肺炎克雷伯氏菌,大肠埃希氏菌体内保护实验的ED_(50)分别为62.26、7.65、209.13、280.87mg/kg;对照药红霉素的ED_(50)分别为35.74、7.87、235.89、324.13mg/kg。结论:两种药物对金黄色葡萄球菌、肺炎链球菌的体内保护作用显著;地红霉素对金黄色葡萄球菌的体内保护作用次于红霉素;对肺炎链球菌的作用两药基本相同;对肺炎克雷伯氏菌、大肠埃希氏菌的保护作用,地红霉素明显优于红霉素。
In order to understand the antibacterial effect of erythromycin in vivo, erythromycin and erythromycin were used in vivo to protect mice. The results showed that the ED 50 of the erythromycin against Staphylococcus aureus, Streptococcus pneumoniae, Klebsiella pneumoniae and Escherichia coli were 62.26, 7.65, 209.13 and 280.87 mg / kg, respectively. The control erythromycin ED_ (50) were 35.74,7.87,235.89,324.13mg / kg. Conclusion: The in vivo protective effects of two drugs on Staphylococcus aureus and Streptococcus pneumoniae were significant. The protective effect of D-erythromycin on Staphylococcus aureus was inferior to that of Erythromycin. The two drugs against S. pneumoniae were basically the same. For Klebsiella pneumoniae, Escherichia coli protective effect, to erythromycin significantly better than erythromycin.