多巴酚丁胺

来源 :中国药学杂志 | 被引量 : 0次 | 上传用户:gaozhanlong
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本品为白色结晶粉末,略溶于水。分子式为:C_(18)H_(24)ClNO_3,分子量为337.85。本品是在异丙肾上腺素的结构改进中发现的,收载于美国20版药典。它保留了异丙肾上腺素正性肌力作用,并能增加心输出量和收缩力而不增加心搏率,也不显著改变总外周的阻力和动脉压,为一抗心力衰竭新药。国内由上海第一制药厂试制成功,并于1985 This product is white crystalline powder, slightly soluble in water. Molecular formula is: C_ (18) H_ (24) ClNO_3, the molecular weight of 337.85. This product is found in the structural improvement of isoproterenol, contained in the United States 20 Pharmacopoeia. It retains the positive inotropic effect of isoproterenol and increases cardiac output and contractility without increasing heart rate, nor does it significantly alter total peripheral resistance and arterial pressure, making it a defensive new drug for heart failure. Domestic first trial by the Shanghai Pharmaceutical Factory trial success, and in 1985
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