目的探讨早发型重度子痫前期期待治疗的临床意义及妊娠结局。方法回顾性分析2002年1月～2007年1月期间,我院收治的早发型重度子痫前期病例112例,根据其发病孕周不同分为三组,即A组(孕周<28周),B组(28周≤孕周<32周),C组(32周≤周<34周),比较各组期待治疗孕产妇及围产儿并发症的发生情况。结果①早发型重度子痫前期病例发病时间越早,孕产妇并发症越多,但三组间无显著性差异(P>0.05)。②三组间胎死宫内、新生儿窒息、新生儿死亡的发生率有显著性差异,发病越早,围产儿并发症的发病率越高(P<0.05)。③三组中B组的期待治疗时间明显多于A和C组(P<0.01),A组和C组间差异无统计学意义。三组终止妊娠时间有显著性差异(P<0.05)。结论早发型重度子痫前期在不同孕周的妊娠结局有差异。在期待治疗过程中应严密监护母体胎儿情况,适时终止妊娠,以减少母婴并发症的发生。 Objective To investigate the clinical significance and pregnancy outcome of early-onset severe preeclampsia. Methods A retrospective analysis of 112 cases of early-onset severe preeclampsia in our hospital from January 2002 to January 2007 were divided into three groups according to their gestational age: group A (gestational age <28 weeks) , Group B (28 weeks ≤ gestational weeks <32 weeks) and group C (32 weeks ≤ weeks <34 weeks). The incidence of complications of expectant mothers and perinatals in each group was compared. Results ① The onset time of early-onset severe preeclampsia was earlier and the number of maternal complications was higher. There was no significant difference between the three groups (P> 0.05). ② The incidence of neonatal asphyxia and neonatal death in the three groups were significantly different. The earlier the morbidity was, the higher the incidence of perinatal complications was (P <0.05). ③ The expected treatment time of group B in the three groups was significantly more than that in groups A and C (P <0.01). There was no significant difference between group A and group C. Three groups of termination of pregnancy have significant differences (P <0.05). Conclusions Early pregnant women with severe preeclampsia have different pregnancy outcomes at different gestational weeks. In the process of looking forward to treatment should be closely monitored maternal fetus, timely termination of pregnancy, in order to reduce the incidence of maternal and child complications.