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在以原代地鼠肾细胞培养生产狂犬病疫苗工艺的基础上,通过对病毒收获液的浓缩倍数、灭活方式的改进及优化、冻干稳定剂的筛选、冻干曲线的确立,制备出了冻干疫苗,其质量及稳定性较液体疫苗有了整体水平的提高,各项检定结果均符合《中国生物制品规程》(2000版)。
Based on the process of producing rabies vaccine by primary mouse kidney cell culture, the enrichment ratio of virus harvest liquid, improvement and optimization of inactivation method, screening of freeze-drying stabilizer and establishment of freeze-drying curve were prepared The quality and stability of the freeze-dried vaccine are generally higher than that of the liquid vaccine. The test results are in accordance with the “China Biological Products Regulations” (2000 version).