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目的对血液灌流抢救有机磷中毒(AOPP)进行临床观察。方法选择两年来在我院就诊AOPP100例,随机分为治疗组与对照组,两组患者均给予常规抢救:反复洗胃、清洗皮肤、减少毒物再吸收,阿托品、解磷定的应用,利尿排毒等支持及对症治疗。治疗组尽早给予血液灌流。观察阿托品化所需时间、阿托品化量、治愈所需时间及阿托品总量、阿托品化及治愈时胆碱酯酶(CHE)活力恢复程度以及阿托品中毒(AP)、阿托品依赖(AD)、反跳(OPR)、呼吸衰竭(RF)、中间综合征(IMS)和猝死(SD)发生率。结果治疗组阿托品化时间、治愈所需时间缩短,阿托品化量及总量减少,治愈时胆碱酯酶(CHE)活力恢复程度增高。AP、AD、OPR、RF、IMS和SD发生率下降。结论血液灌流(HP)通过清除血液内有机磷毒物取得了显著临床效果。
Objective To study the clinical effect of hemoperfusion on organophosphate poisoning (AOPP). Methods One hundred cases of AOPP were selected in our hospital for two years. The patients were randomly divided into treatment group and control group. Patients in both groups were given routine resuscitation: repeated gastric lavage, cleansing skin, reducing reabsorption of arsenic, application of atropine, Support and symptomatic treatment. The treatment group was given hemoperfusion as soon as possible. To observe the time required for atropine, the amount of atropine, the time required for healing and the total amount of atropine, atropine and cure recovery of cholinesterase (CHE) activity and atropine poisoning (AP), atropine dependence (AD), rebound (OPR), respiratory failure (RF), intermediate syndrome (IMS) and sudden death (SD). Results In the treatment group, the time of atropisation, the time required for the cure, the amount of atropine and the amount of atropine were reduced, and the degree of recovery of CHE activity was increased after the treatment. The incidence of AP, AD, OPR, RF, IMS and SD decreased. Conclusion Hemoperfusion (HP) achieved significant clinical effect by removing organophosphate poison from the blood.