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目的观察急性脑梗死患者治疗前后血浆D-二聚体的变化,并探讨其临床意义。方法测定发病24h内的脑梗死患者治疗前及治疗3周后血浆D-二聚体含量,并将两组结果与正常对照者血浆D-二聚体含量比较。结果急性脑梗死患者治疗前血浆D-二聚体含量明显高于对照组(P<0.01),而治疗3周后血浆D-二聚体含量显著下降,其数值与对照组相近(P>0.05)。结论脑梗死患者发病24h内存在凝血纤溶系统异常,治疗3周后凝血纤溶系统基本恢复正常,血浆D-二聚体对脑梗死患者的诊断、病情及疗效判断有重要的参考价值。
Objective To observe the changes of plasma D-dimer in patients with acute cerebral infarction before and after treatment, and to explore its clinical significance. Methods Plasma D-dimer levels were measured before treatment and after 3 weeks of treatment in patients with cerebral infarction within 24 hours after onset of onset. The plasma D-dimer levels in two groups were compared with those in normal controls. Results Before treatment, the plasma D-dimer level in patients with acute cerebral infarction was significantly higher than that in the control group (P <0.01), and the plasma D-dimer level decreased significantly after 3 weeks of treatment, which was similar to that of the control group (P> 0.05 ). Conclusion There is an abnormal coagulation and fibrinolytic system in patients with cerebral infarction within 24 hours of onset. The coagulation and fibrinolytic system basically returns to normal after 3 weeks of treatment. Plasma D-dimer has important reference value for the diagnosis, diagnosis and treatment of cerebral infarction.