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目的对于冠心病患者的诊断、预后判断提供参考。方法对近年来关于炎性标志物与冠心病的一些诊断、预后判断回顾性研究进行分析、归纳、总结。结果C反应蛋白、金属基质蛋白酶、孕相关血浆蛋白-A、脂蛋白相关磷脂酶A2、髓过氧化物酶、白介素-18等在冠心病患者中升高,与冠心病事件相关,可作为预后判断的指标。金属基质蛋白酶、孕相关血浆蛋白-A、脂蛋白相关磷脂酶A2、髓过氧化物酶等与冠心病斑块的稳定性相关。C反应蛋白、孕相关血浆蛋白-A等可为冠心病患者的诊断提供参考。结论具有高度敏感性、特异性的炎性标记物的研究已成为临床研究的热点,对于ACS的诊断、预后判断已显示出一定的价值。今后还需要进一步的研究证实或检验一些炎性标记物的临床意义。
Objective To provide a reference for the diagnosis and prognosis of patients with coronary heart disease. Methods In recent years, some retrospective studies on the diagnosis and prognosis of inflammatory markers and coronary heart disease were analyzed, summarized and summarized. Results C-reactive protein, matrix metalloproteinase, pregnancy-associated plasma protein-A, lipoprotein-associated phospholipase A2, myeloperoxidase, interleukin-18 and other elevated in patients with coronary heart disease, and coronary heart disease events can be used as a prognosis Judgment indicators. Metal matrix protease, pregnancy related plasma protein-A, lipoprotein-associated phospholipase A2, myeloperoxidase and coronary heart disease plaque stability. C-reactive protein, pregnancy-related plasma protein-A can provide a reference for the diagnosis of patients with coronary heart disease. Conclusion The study of highly sensitive and specific inflammatory markers has become a hot topic in clinical research. It has shown some value in the diagnosis and prognosis of ACS. In the future, further research is needed to confirm or test the clinical significance of some inflammatory markers.